Poly-L-glutamic acid-poly-N-isopropylacrylamide graft copolymers and methods of preparation invented by the researcher of Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, etc., have recently obtained national invention patents.
The invention uses hydrogen bromide or catalytic hydrogenation to reduce benzyl group to obtain poly N-isopropylacrylamide-polyamino acid diblock copolymer. The copolymer has dual influence on temperature and pH in aqueous solution, can be biodegradable, and degradation residue can be directly eliminated from the body through the kidney. Therefore, it can be used as a carrier for targeted drug release in vivo in biomedical and pharmaceutical fields. Injection type smart responsive hydrogel.
The invention uses hydrogen bromide or catalytic hydrogenation to reduce benzyl group to obtain poly N-isopropylacrylamide-polyamino acid diblock copolymer. The copolymer has dual influence on temperature and pH in aqueous solution, can be biodegradable, and degradation residue can be directly eliminated from the body through the kidney. Therefore, it can be used as a carrier for targeted drug release in vivo in biomedical and pharmaceutical fields. Injection type smart responsive hydrogel.